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Search Results for " complement c5a anaphylatoxin "

Targets Recommended: ROS Complement System

3

抑制剂 & 化合物

3

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T17250	W-54011	ROS; Complement System	Immunology/Inflammation
	W-54011 是口服有效的非肽 C5a 受体拮抗剂，抑制125I 标记的 C5a 与人嗜中性白细胞的结合，Ki 为 2.2 nM。它还抑制C5a 诱导的人嗜中性粒细胞的细胞内 Ca2+动员，趋化性和ROS 的生成，IC50分别为 3.1 nM、2.7 nM 和1.6 nM。
T82797	C5aR1 antagonist peptide
	C5aR1 antagonist peptide 是一种源自C5a (趋化因子补体片段5过敏毒素) C末端的生物活性线性肽。它能在人和大鼠的C5a受体上阻断C5a的结合，对于细胞免疫反应的触发起着关键作用。C5a的过度表达与多种免疫炎性疾病如关节炎、阿尔茨海默病、囊性纤维化和系统性红斑狼疮等有着密切关联。
T80265	C5a Receptor agonist, mouse, human	Complement System	Immunology/Inflammation
	C5a Receptor agonist, mouse, human 是一种源自血浆蛋白C5a C末端的生物活性肽，充当C5a受体激动剂。此化合物在调控细胞炎症反应中起关键作用，包括促进趋化性、白细胞脱颗粒、增加血管通透性以及刺激细胞因子的产生。化合物的结构中，第5位环己基丙氨酸对激动剂功能至关重要，同时末端的Arg采用d-异构体形式。

化合物

Cat.No: T17250

Target: ROS, Complement System

C5aR1 antagonist peptide

Cat.No: T82797

C5a Receptor agonist, mouse, human

Cat.No: T80265

Target: Complement System

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-03107	Complement C5a Protein, Pig, Recombinant (His) Complement C5a anaphylatoxin,C5	Sus scrofa (Pig)	P. pastoris (Yeast)
	Derived from proteolytic degradation of complement C5, C5a anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation....
TMPH-03529	Chemotaxis inhibitory Protein, S. aureus (strain MRSA252), Recombinant (His) CHIPS,Chemotaxis inhibitory protein,chp	Staphylococcus aureus	P. pastoris (Yeast)
	Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of human neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leucyl-phenylalanine (fMLP). Acts by binding directly to the C5a receptor (C5aR) and formylated peptide receptor (FPR), thereby blocking the C5a- and fMLP-induced calcium responses. Prevents phagocytosis of the bacterium. Chemotaxis inhibitory Protein, S. aureus (strain MRSA252), Re...
TMPH-03528	Chemotaxis inhibitory Protein, S. aureus (strain NCTC 8325/PS47), Recombinant (His & Myc) chp,Chemotaxis inhibitory protein,CHIPS	Staphylococcus aureus	E. coli
	Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of human neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leucyl-phenylalanine (fMLP). Acts by binding directly to the C5a receptor (C5aR) and formylated peptide receptor (FPR), thereby blocking the C5a- and fMLP-induced calcium responses. Prevents phagocytosis of the bacterium. Chemotaxis inhibitory Protein, S. aureus (strain NCTC 8325/PS...

重组蛋白

Complement C5a Protein, Pig, Recombinant (His)

Cat.No: TMPH-03107

Species: Sus scrofa (Pig)

Expression System: P. pastoris (Yeast)

Chemotaxis inhibitory Protein, S. aureus (strain MRSA252), Recombinant (His)

Cat.No: TMPH-03529

Species: Staphylococcus aureus

Expression System: P. pastoris (Yeast)

Chemotaxis inhibitory Protein, S. aureus (strain NCTC 8325/PS47), Recombinant (His & Myc)

Cat.No: TMPH-03528

Species: Staphylococcus aureus

Expression System: E. coli

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